上海交通大学,医学院-瑞金医院,研究员

毕业于中国科学院健康科学研究所，从事肿瘤应激调控机制及临床前转化研究。聚焦肿瘤对微环境的响应和重塑机制，获得延续性进展，研究成果发表在专业杂志Journal of Clinical Investigation, Neuro-Oncology, JNCI-Journal of the National Cancer Institute、Bone Research等，共发表20篇JCR/Q1区论文；申报了10余项国家发明专利；并相继获得国家自然科学基金-青年项目，面上项目（2017、2022、2025）和上海市科委等7个项目支持；担任中华医学会放射肿瘤治疗学分会（生物学组、FLASH放疗学组）、上海市抗癌协会神经肿瘤专业委员会、中国研究型医院学会医学动物实验专家委员会的委员、Oncology Research、VIEW、Brain-X、Medicine Bulletin的编委或青年编委；Advanced Materials，Nature Communications, Cancer Research, Cancer Letters, iScience等审稿专家。

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一、 教育经历

2003.9-2007.7 浙江大学生命科学学院 理学学士

2007.9-2013.7 中国科学院健康科学研究所 生物化学与分子生物学博士学位

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二、科研与学术工作经历

2025.1-至今 上海交通大学医学院附属瑞金医院放射治疗科、上海市质子重点实验室、研究员

2017.1-2024.12 上海交通大学医学院附属仁济医院神经外科暨上海市颅脑创伤研究所、副研究员

2013.8-2016.12 上海交通大学医学院附属仁济医院神经外科暨上海市颅脑创伤研究所、助理研究员

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三、主要获得奖项

入选交通大学晨星计划和上海市青年英才扬帆计划

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四、近期主持及在研项目

2026-01-01—2029-12-31，国家自然科学基金-面上项目，批准号：82573100，ZDHHC20-AEP-TIA1轴重塑精氨酸依赖的肿瘤-神经互作促使胶质母细胞瘤放疗抵抗机制研究

2023-01-01—2026-12-31，国家自然科学基金-面上项目，批准号：82273278，肿瘤微环境触发AEP酶切TMOD3促进胶质母细胞瘤浸润性生长的机制研究

2018-01-01—2021-12-31，国家自然科学基金-面上项目，批准号：81772654，天冬酰胺内肽酶通过微囊泡转运驯化基质细胞促进胶质母细胞瘤发展的机制研究

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五、代表性论文

(1) Zhonggang Shi, Jianyi Zhao, Qi Lv, Keman Liao, Lu Cao, Jian Yang, Mengying Wang, Li Zhou, Haoping Xu, Jianwei Ge, Yongming Qiu, Juxiang Chen, Jiayi Chen, Chunhui Ma; Lin Yingying; Chemotherapeutic drug-triggered AEP-cleaved G3BP1 orchestrates stress granules/nucleoli/mitochondria in osteosarcoma, Bone Research, 2025, 10.1038/s41413-025-00453-w.

(2) Jianyi Zhao; Linshi Wu; Gang Cai; Dan Ou; Keman Liao; Jian Yang; Li Zhou; Renhua Huang; Shukai Lin; Xi Huang; Qi Lv; Juxiang Chen; Lu Cao; Jiayi Chen; Lin Yingying; Targeting PEG2 mediated senescent neuron improves tumour therapy, Neuro-Oncology, 2025, 2(18): noaf045.

(3) Jianyi Zhao; Lilin Cheng; Jian Yang; Feifei Xu; Weixiang Qi; Keman Liao; Li Zhou; Lu Cao; Jiayi Chen; Lin Yingying; Tumor-nerve interactions in cancer regulation and progression, Cancer Letters, 2025, 612(2025): 217483.

(4) Keman Liao; Yan Gao; Mengdan Cheng; Yibing Zhang; Jianyi Zhao; Li Zhou; Ran Wu; Gang Cai; Lu Cao; Jiayi Chen; Lin Yingying; Intranasal delivery of AEP inhibitor-loaded neuron-targeted liposome ameliorates radiation-induced brain injury, Materials Today Bio, 2025, 31(2025):101568.

(5) Qiu Ouwen; Zhao Jianyi; Shi Zhonggang; Li Huan; Wang Siyuan; Liao Keman; Tang Minchao; Xie Jieqiong; Huang Xi; Zhang Wenrui; Zhou Li; Yang Xi; Zhou Zhiyi; Xu Lei; Huang Renhua; Miao Yifeng; Qiu Yongming; Lin Yingying; Asparagine endopeptidase deficiency mitigates radiation-induced brain injury by suppressing microglia-mediated neuronal senescence, iSCIENCE, 2024,27(5):109698.

(6) Zhang Wenrui; Cao Lu; Yang Jian; Zhang Shuai; Zhao Jianyi; Shi Zhonggang; Liao Keman; Wang Haiwei; Chen Binghong; Qian Zhongrun; Xu Haoping; Wu Linshi; Liu Hua; Wang Hongxiang; Ma Chunhui; Qiu Yongming; Ge Jianwei; Chen Jiayi; Lin Yingying; AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironment, Journal of Clinical Investigation, 2023,JCI173299.

(7) Chen Binghong; Wang Mengying; Qiu Junjun; Liao Keman; Zhang Wenrui; Lv Qi; Ma Chunhui; Qian Zhongrun; Shi Zhonggang; Liang Rong; Lin Yan; Ye Jiazhou; Qiu Yongming; Lin Yingying; Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling, Journal of Experimental & Clinical Cancer Research, 2022, 41(1).

(8) Sun SG; Guo JJ; Qu XY; Tang XY; Lin YY; Hua KQ, Qiu JJ; The extracellular vesicular pseudogene LGMNP1 induces M2-like macrophage polarization by upregulating LGMN and serves as a novel promising predictive biomarker for ovarian endometriosis recurrence, Human Reproduction, 2022 Mar 1;37(3):447-465.

(9) Chen, Binghong; Wang, Mengying; Huang, Renhua; Liao, Keman; Wang, Tianwei; Yang, Renhao; Zhang, Wenrui; Shi, Zhonggang; Ren, Li; Lv, Qi; Ma, Chunhui; Lin, Yingying; Qiu, Yongming; Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis, Cancer Letters, 2021, 522(2021): 225-237.

(10) Lin Yingying; Liao Keman; Miao Yifeng; Qian Zhongrun; Fang Zhaoyuan; Yang Xi; Nie Quanmin; Jiang Gan; Liu Jianhua; Yu Yiyi; Wan Jieqing; Zhang Xiaohua; Hu Yaomin; Jiang Jiyao; Qiu Yongming; Role of asparagine endopeptidase in mediating wild-type p53 inactivation of glioblastoma, JNCI-Journal of the National Cancer Institute, 2020, 112(4): djz155.

(11) Liao Keman; Qian Zhongrun; Zhang Shuai; Chen Binghong; Li Zhiqiang; Huang Renhua; Cheng Lilin; Wang Tianwei; Yang Renhao; Lan Jin; Lu Xiaojie; Kong Lin; Song Xiwen; Qiu Yongming; Lin Yingying; The LGMN pseudogene promotes tumor progression by acting as a miR-495-3p sponge in glioblastoma, Cancer letters, 2020, 490(2020): 111-123.

(12) Qiu Junun; Sun Shugen; Tang Xiaoyan; Lin Yingying; Hua Keqin; Extracellular vesicular Wnt7b mediates HPV E6-induced cervical cancer angiogenesis by activating the β-catenin signaling pathway, Journal of Experimental & Clinical Cancer Research, 2020, 39(260).

(13) Liao Keman; Lin Yingying; Gao Weizhen; Xiao Zhipeng; Medina Rogelio; Dmitriev Pauline; Cui Jing; Zhuang Zhengping; Zhao Xiaochun; Qiu Yongming; Zhang Xiaohua; Ge Jianwei; Guo Liemei; Blocking lncRNA MALAT1/miR-199a/ZHX1 Axis Inhibits Glioblastoma Proliferation and Progression, Molecular Therapy-Nucleic Acids, 2019(18): 388-399.

(14) Chen Xi; Wang Chen; Liao Keman; Zhou Sunhai; Cao Lu; Chen Jiayi; Xu Chen; Lin Yingying; USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP, International Journal of Biological Sciences, 2019,15(4):738-748.